THESES

MS Theses available

Development of a “immune- and gut-on-a-chip” millifluidic systems in the context of a multi-organ platform suitable for brain drug testing (PEGASO project, Fig.1)

Start date: April 2022

Background: Organ-on-a-chip are innovative and forefront solutions for several biomedical applications, including drug screening or testing. The PEGASO project aims to develop the first induced pluripotent stem cells (iPSC)-based multiorgan-on-a-chip platform for Alzheimer’s disease drug development (Figure1). The full platform will be composed of six OoC devices connected and loaded with iPSC-derived models representing the main organs involved in dementia drug pharmacokinetics.  In particular, within the PEGASO project we want to focus on the development of engineered in vitro models of immune system and intestine to be hosted inside the OoC, taking advantage from a strong interaction with the ERC funded MINERVA project (http://www.minerva.polimi.it/) which aims to develop a multi organ-on-a-chip-platform to study microbiota impact on brain functionality.

Aim: The candidate will earn competences in in vitro modelling, biomaterials, biology, microfluidic, experimental set up design and computational fluid dynamic modelling. We are looking for highly motivated candidates with interests in biology, biomaterials and advanced cell culture systems.

The experimental activities will be performed at the Laboratory of Biology of Neurodegenerative Disorders (IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan) under the supervision of Dott. Diego Albani.

Tutor: Dott. Francesca Fanizza Ph.D. student, Dott Diego Albani, Prof. Carmen Giordano

For further information, please, contact us by e-mail at francesca.fanizza@polimi.it